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Article

GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region.

The Journal of biological chemistry - 23 Apr 2004

Bai Hongdong, Doray Balraj, Kornfeld Stuart

Abstract excerpt

The Golgi-associated gamma-adaptin-related ADP-ribosylation factor-binding proteins (GGAs) are critical components of the transport machinery that mediates the trafficking of the mannose 6-phosphate receptors and associated cargo from the trans-Golgi network to the endosomes. The GGAs colocalize...

Read the complete abstract on PubMed

Topics

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Share to Adaptor Proteins, Vesicular Transport
Share to ADP-Ribosylation Factors
Share to Binding, Competitive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14973137
DOI: 10.1074/jbc.M401158200

Genes

GGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14973137-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region.PMID 14973137Read ↗

Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.Semantic proximity Read ↗

Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2.Semantic proximity Read ↗

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.Semantic proximity Read ↗

The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding.Semantic proximity Read ↗

AAGAB is an assembly chaperone regulating AP1 and AP2 clathrin adaptorsSemantic proximity Read ↗

GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination.Semantic proximity Read ↗

Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs).Semantic proximity Read ↗

Epidermal growth factor-dependent phosphorylation of the GGA3 adaptor protein regulates its recruitment to membranes.Semantic proximity Read ↗

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A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR.Semantic proximity Read ↗

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.Semantic proximity Read ↗

Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.Semantic proximity Read ↗

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