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Article

Critical role of the CMGC insert sequence for tyrosine autophosphorylation in the protein kinase DYRK1B.

Scientific reports - 24 Dec 2025

Detro-Dassen Silvia, Schwandt Katharina, Helmich Philip, Düsterhöft Stefan, Becker Walter

Abstract excerpt

Many CMGC group kinases require phosphorylation of a conserved tyrosine residue in the activation loop to achieve catalytic activity. DYRK family members use a distinctive mechanism involving constitutive cis-autophosphorylation of this tyrosine. The structural basis of this process has remained unclear, as it occurs while the kinase is still in an inactive conformation, and the tyrosine does not match the known...

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Source

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Identifiers

PMID: 41444824
DOI: 10.1038/s41598-025-33562-x
PMCID: PMC12738607

Genes

DYRK1B
DYRK1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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