Article
Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.
Science (New York, N.Y.) - 1 Jun 2001
Zhu Y, Doray B, Poussu A, Lehto V P, Kornfeld S
Abstract excerpt
The GGAs are a multidomain protein family implicated in protein trafficking between the Golgi and endosomes. Here, the VHS domain of GGA2 was shown to bind to the acidic cluster-dileucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR). Receptors with mutations in this motif were defective in lysosomal enzyme sorting. The hinge domain of GGA2 bound clathrin,...
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