Article
The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation.
Science signaling - 8 Feb 2011
Jones Janice C, Duffy Jeffrey W, Machius Mischa, Temple Brenda R S, Dohlman Henrik G, Jones Alan M
Abstract excerpt
In animals, heterotrimeric guanine nucleotide-binding protein (G protein) signaling is initiated by G protein-coupled receptors (GPCRs), which activate G protein α subunits; however, the plant Arabidopsis thaliana lacks canonical GPCRs, and its G protein α subunit (AtGPA1) is self-activating. To investigate how AtGPA1 becomes activated, we determined its crystal structure. AtGPA1 is structurally similar to animal...
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