Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer.

doi:10.1158/1055-9965.EPI-09-0289

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Article

Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2009

de Vogel Stefan, Wouters Kim A D, Gottschalk Ralph W H, van Schooten Frederik J, de Goeij Anton F P M, de Bruïne Adriaan P, Goldbohm Royle A, van den Brandt Piet A, Weijenberg Matty P, van Engeland Manon

Abstract excerpt

Aberrant DNA methylation affects carcinogenesis of colorectal cancer. Folate metabolizing enzymes may influence the bioavailability of methyl groups, whereas DNA and histone methyltransferases are involved in epigenetic regulation of gene expression. We studied associations of genetic variants of folate metabolizing enzymes (MTHFR, MTR, and MTRR), DNA methyltransferase DNMT3b, and histone methyltransferases...

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Identifiers

PMID: 19843671
DOI: 10.1158/1055-9965.EPI-09-0289

Genes

MTR
MLH1
EHMT2
MTHFR
MTRR
EHMT1
PRDM2

Variants

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Source receipt: pubmed, retrieved 7 Sept 2026.

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