Article
Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2015
Weisenberger Daniel J, Levine A Joan, Long Tiffany I, Buchanan Daniel D, Walters Rhiannon, Clendenning Mark, Rosty Christophe, Joshi Amit D, Stern Mariana C, LeMarchand Loic, Lindor Noralane M, Daftary Darshana, Gallinger Steven, Selander Teresa, Bapat Bharati, Newcomb Polly A, Campbell Peter T, Casey Graham, Ahnen Dennis J, Baron John A, Haile Robert W, Hopper John L, Young Joanne P, Laird Peter W, Siegmund Kimberly D
Abstract excerpt
BACKGROUND: The CpG island methylator phenotype (CIMP) represents a subset of colorectal cancers characterized by widespread aberrant DNA hypermethylation at select CpG islands. The risk factors and environmental exposures contributing to etiologic heterogeneity between CIMP and non-CIMP tumors are not known. METHODS: We measured the CIMP status of 3,119 primary population-based colorectal cancer tumors from the...
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