Article
Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.
Cancer causes & control : CCC - 1 Jan 2011
de Vogel Stefan, Wouters Kim A D, Gottschalk Ralph W H, van Schooten Frederik J, de Goeij Anton F P M, de Bruïne Adriaan P, Goldbohm R Alexandra, van den Brandt Piet A, van Engeland Manon, Weijenberg Matty P
Abstract excerpt
Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). Among 609 CRC cases and 1,663 subcohort members of the Netherlands Cohort Study on diet and cancer (n = 120,852), we estimated CRC risk according to methyl donor intake across genotypes of folate metabolizing enzymes and methyltransferases.Although diet-gene interactions were not statistically significant,...
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