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Article

Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer

17 Oct 2019

Abstract excerpt

BACKGROUND: CpG Island Methylator Phenotype (CIMP) is an epigenetic phenotype in CRC characterized by hypermethylation of CpG islands in promoter regions of tumor suppressor genes, leading to their transcriptional silencing and loss of function. While the prevalence of CRC differs across geographical regions, no studies have compared prevalence of CIMP-High phenotype across regions. The purpose of this project...

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PMID: 31623592
DOI: 10.1186/s12885-019-6144-9

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