Article
Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer.
Carcinogenesis - 1 Sept 2008
de Vogel Stefan, Bongaerts Brenda W C, Wouters Kim A D, Kester Arnold D M, Schouten Leo J, de Goeij Anton F P M, de Bruïne Adriaan P, Goldbohm R Alexandra, van den Brandt Piet A, van Engeland Manon, Weijenberg Matty P
Abstract excerpt
Intake of dietary factors that serve as methyl group donors may influence promoter hypermethylation in colorectal carcinogenesis. We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes of MLH1 protein expression, microsatellite instability (MSI) and BRAF mutations in patients with...
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