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MLH1 gene promoter methylation status partially overlaps with CpG methylator phenotype (CIMP) in colorectal adenocarcinoma

21 Dec 2024

Abstract excerpt

RAS / BRAF mutations, mismatch DNA repair complex deficiency (MMRd)/microsatellite instability (MSI), and CpG methylator phenotype (CIMP) are key molecular actors in colorectal carcinogenesis. To date, conflicting evidence about the correlations between these molecular features has been reported. A retrospectively selected cohort of 123 CRCs was divided into 3 groups based on the molecular characteristics: MMR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39724851
DOI: 10.1016/j.prp.2024.155786

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