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Article

Polymorphisms in methyl-group metabolism genes and risk of sporadic colorectal cancer with relation to the CpG island methylator phenotype.

Cancer epidemiology - 1 Jun 2010

Karpinski Pawel, Myszka Aleksander, Ramsey David, Misiak Blazej, Gil Justyna, Laczmanska Izabela, Grzebieniak Zygmunt, Sebzda Tadeusz, Smigiel Robert, Stembalska Agnieszka, Sasiadek Maria M

Abstract excerpt

BACKGROUND: The CpG island methylator phenotype (CIMP), together with extensive promoter methylation, is regarded as one of the mechanisms involved in colorectal carcinogenesis. The mechanisms underlying CIMP in sporadic colorectal cancer are poorly understood. Genes involved in methyl-group metabolism are likely to affect DNA methylation and thereby influence an individual's risk of CIMP. The aim of the present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20381446
DOI: 10.1016/j.canep.2010.03.002

Genes

BRAF
IGF2
MTHFR
NEUROG1
RUNX3
SOCS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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