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Article

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.

Nature genetics - 1 Jul 2006

Weisenberger Daniel J, Siegmund Kimberly D, Campan Mihaela, Young Joanne, Long Tiffany I, Faasse Mark A, Kang Gyeong Hoon, Widschwendter Martin, Weener Deborah, Buchanan Daniel, Koh Hoey, Simms Lisa, Barker Melissa, Leggett Barbara, Levine Joan, Kim Myungjin, French Amy J, Thibodeau Stephen N, Jass Jeremy, Haile Robert, Laird Peter W

Abstract excerpt

Aberrant DNA methylation of CpG islands has been widely observed in human colorectal tumors and is associated with gene silencing when it occurs in promoter areas. A subset of colorectal tumors has an exceptionally high frequency of methylation of some CpG islands, leading to the suggestion of a distinct trait referred to as 'CpG island methylator phenotype', or 'CIMP'. However, the existence of CIMP has been...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16804544
DOI: 10.1038/ng1834

Genes

BRAF
MLH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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