Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women.

Journal of lipid research - 1 Mar 2010

Hamrefors Viktor, Orho-Melander Marju, Krauss Ronald M, Hedblad Bo, Almgren Peter, Berglund Göran, Melander Olle

Abstract excerpt

While conventional pharmacogenetic studies have considered single gene effects, we tested if a genetic score of nine LDL- and HDL-associated single nucleotide polymorphisms, previously shown to predict cardiovascular disease, is related to fluvastatin-induced lipid change. In patients with asymptomatic plaque in the right carotid artery, thus candidates for statin therapy, we related score LDL [APOB(rs693),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenergic beta-Antagonists

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, HDL

Share to Cholesterol, LDL

Share to Cohort Studies

Share to Fatty Acids, Monounsaturated

Share to Indoles

Share to Polymorphism, Single Nucleotide

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 19773416
DOI: 10.1194/jlr.P001792
PMCID: PMC2817592

Genes

ABCA1
APOB
APOE
CETP
HMGCR
LDLR
LIPC
LPL
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women.PMID 19773416Read ↗

A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.Semantic proximity Read ↗

Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease.Semantic proximity Read ↗

A genetic risk score is significantly associated with statin therapy response in the elderly population.Semantic proximity Read ↗

Impact of variants within seven candidate genes on statin treatment efficacy.Semantic proximity Read ↗

Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins.Semantic proximity Read ↗

Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation.Semantic proximity Read ↗

Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke.Semantic proximity Read ↗

Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, and CYP7A1 genes as predictors of lipid-lowering response to atorvastatin therapy.Semantic proximity Read ↗

Polymorphisms associated with cholesterol and risk of cardiovascular events.Semantic proximity Read ↗

Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.Semantic proximity Read ↗

Added value of pharmacogenetic testing in predicting statin response: results from the REGRESS trial.Semantic proximity Read ↗

Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.