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Article

A genetic risk score is significantly associated with statin therapy response in the elderly population.

Clinical genetics - 1 Mar 2017

Ciuculete D M, Bandstein M, Benedict C, Waeber G, Vollenweider P, Lind L, Schiöth H B, Mwinyi J

Abstract excerpt

The ability of statins to strongly reduce low-density lipoprotein cholesterol (LDL-C) varies interindividually and is partially influenced by genetic variants. Based on a comprehensive analysis of 23 single nucleotide polymorphisms (SNPs) known to be associated with pharmacokinetics and dynamics of statins, we developed a genetic risk score to study its impact on the therapy outcome in elderly individuals under...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27943270
DOI: 10.1111/cge.12890

Genes

ABCC2
APOE
PSRC1
SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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