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Article

Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2013

Isaacs Aaron, Willems Sara M, Bos Daniel, Dehghan Abbas, Hofman Albert, Ikram M Arfan, Uitterlinden André G, Oostra Ben A, Franco Oscar H, Witteman Jacqueline C, van Duijn Cornelia M

Abstract excerpt

OBJECTIVE: Circulating levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and triglycerides are recognized risk factors for cardiovascular disease. We tested the hypothesis that the cumulative effects of common genetic variants for lipids are collectively associated with subclinical atherosclerosis and incident coronary heart disease. APPROACH AND...

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Identifiers

PMID: 23766260
DOI: 10.1161/ATVBAHA.113.301236

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