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Article

Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins.

Pharmacogenomics - 1 Mar 2010

Chien Kuo-Liong, Wang Kuei-Chen, Chen Yen-Ching, Chao Chia-Lung, Hsu Hsiu-Ching, Chen Ming-Fong, Chen Wei J

Abstract excerpt

AIMS: This study assessed the association between pharmacokinetic- and pharmacodynamic-related genes and individual responses to low-density lipoprotein cholesterol (LDL-C) change by statins in a Chinese population. MATERIALS & METHODS: A total of 386 patients with primary hypercholesterolemia were treated with statins for 9 months. The 62 haplotype-tagging SNPs of ten candidate genes were genotyped. Treating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20235787
DOI: 10.2217/pgs.09.160

Genes

HMGCR
ABCG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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