Article
Added value of pharmacogenetic testing in predicting statin response: results from the REGRESS trial.
The pharmacogenomics journal - 1 Aug 2013
van der Baan F H, Knol M J, Maitland-van der Zee A H, Regieli J J, van Iperen E P A, Egberts A C G, Klungel O H, Grobbee D E, Jukema J W
Abstract excerpt
It was investigated whether pharmacogenetic factors, both as single polymorphism and as gene-gene interactions, have an added value over non-genetic factors in predicting statin response. Five common polymorphisms were selected in apolipoprotein E, angiotensin-converting enzyme, hepatic lipase and toll-like receptor 4. Linear regression models were built and compared on R(2) to estimate the added value of single...
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