Article
Polymorphisms associated with cholesterol and risk of cardiovascular events.
The New England journal of medicine - 20 Mar 2008
Kathiresan Sekar, Melander Olle, Anevski Dragi, Guiducci Candace, Burtt Noël P, Roos Charlotta, Hirschhorn Joel N, Berglund Göran, Hedblad Bo, Groop Leif, Altshuler David M, Newton-Cheh Christopher, Orho-Melander Marju
Abstract excerpt
BACKGROUND: Common single-nucleotide polymorphisms (SNPs) that are associated with blood low-density lipoprotein (LDL) or high-density lipoprotein (HDL) cholesterol modestly affect lipid levels. We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease. METHODS: We studied SNPs at nine loci in 5414 subjects from the cardiovascular cohort of the Malmö Diet and...
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