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Article

Impact of variants within seven candidate genes on statin treatment efficacy.

Physiological research - 1 Jan 2012

Vrablík M, Hubáček J A, Dlouhá D, Lánská V, Rynekrová J, Zlatohlávek L, Prusíková M, Ceška R, Adámková V

Abstract excerpt

Statins are the most commonly used drugs in patients with dyslipidemia. Among the patients, a significant inter-individual variability with supposed strong genetic background in statin treatment efficacy has been observed. Genome wide screenings detected variants within the CELSR2/PSRC1/SORT1, CILP2/PBX4, APOB, APOE/C1/C4, HMGCoA reductase, LDL receptor and PCSK9 genes that are among the candidates potentially...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23098650
DOI: 10.33549/physiolres.932341

Genes

APOE
APOB
CELSR2
CILP2
PBX4
PCSK9
PSRC1
SORT1

Provenance

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