A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.

doi:10.2217/pgs.16.8

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Article

A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering.

Pharmacogenomics - 1 Apr 2016

Leusink Maarten, Maitland-van der Zee Anke H, Ding Bo, Drenos Fotios, van Iperen Erik Pa, Warren Helen R, Caulfield Mark J, Cupples L Adrienne, Cushman Mary, Hingorani Aroon D, Hoogeveen Ron C, Hovingh G Kees, Kumari Meena, Lange Leslie A, Munroe Patricia B, Nyberg Fredrik, Schreiner Pamela J, Sivapalaratnam Suthesh, de Bakker Paul Iw, de Boer Anthonius, Keating Brendan J, Asselbergs Folkert W, Onland-Moret N Charlotte

Abstract excerpt

AIM: To find new genetic loci associated with statin response, and to investigate the association of a genetic risk score (GRS) with this outcome. PATIENTS & METHODS: In a discovery meta-analysis (five studies, 1991 individuals), we investigated the effects of approximately 50000 single nucleotide polymorphisms on statin response, following up associations with p < 1 × 10(-4) (three independent studies, 5314...

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Identifiers

PMID: 27045730
DOI: 10.2217/pgs.16.8
PMCID: PMC5558527

Genes

ABCG2
APOE
LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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