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Article

Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

European heart journal - 1 Apr 2013

Hopewell Jemma C, Parish Sarah, Offer Alison, Link Emma, Clarke Robert, Lathrop Mark, Armitage Jane, Collins Rory

Abstract excerpt

AIMS: Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains uncertain whether there is clinically relevant genetic variation in their efficacy. This study of 18 705 individuals aims to identify genetic variants related to the lipid response to simvastatin and assess their impact on vascular risk response. METHODS AND RESULTS: A genome-wide study of the LDL-C and apolipoprotein B...

Topics

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Anticholesteremic Agents
Apolipoproteins B
Cardiovascular Diseases
Cholesterol, LDL
Hypercholesterolemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multidrug Resistance-Associated Protein 2

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Open in PubMed Open full text

Identifiers

PMID: 23100282
DOI: 10.1093/eurheartj/ehs344
PMCID: PMC3612775

Genes

LPA
APOE
ABCC2
CELSR2
PSRC1
SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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