Article
Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.
Atherosclerosis - 1 Sept 2008
Polisecki Eliana, Muallem Hind, Maeda Nobuyo, Peter Inga, Robertson Michele, McMahon Alex D, Ford Ian, Packard Christopher, Shepherd James, Jukema J Wouter, Westendorp Rudi G J, de Craen Anton J M, Buckley Brendan M, Ordovas Jose M, Schaefer Ernst J
Abstract excerpt
Our purpose was to evaluate associations of single nucleotide polymorphisms (SNPs) at the low density lipoprotein (LDL) receptor (LDLR C44857T, minor allele frequency (MAF) 0.26, and A44964G, MAF 0.25, both in the untranslated region) and HMG-CoA reductase (HMGCR i18 T>G, MAF 0.019) gene loci with baseline lipid values, statin-induced LDL-cholesterol (C) lowering response, and incident coronary heart disease...
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