Article
Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.
Atherosclerosis - 1 Feb 2012
Congrains Ada, Kamide Kei, Oguro Ryousuke, Yasuda Osamu, Miyata Keishi, Yamamoto Eiichiro, Kawai Tatsuo, Kusunoki Hiroshi, Yamamoto Hiroko, Takeya Yasushi, Yamamoto Koichi, Onishi Miyuki, Sugimoto Ken, Katsuya Tomohiro, Awata Nobuhisa, Ikebe Kazunori, Gondo Yasuyuki, Oike Yuichi, Ohishi Mitsuru, Rakugi Hiromi
Abstract excerpt
UNLABELLED: Genome-wide association studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD-associated region is adjacent to the two cyclin dependent kinase inhibitors (CDKN)2A and 2B and the last exons of the non-coding RNA, ANRIL. It is still not clear which of or how these transcripts are involved in the pathogenesis of...
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