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Article

The mechanisms of Chr.9p21.3 risk locus in coronary artery disease: where are we today?

American journal of physiology. Heart and circulatory physiology - 1 Feb 2025

Ruotsalainen Anna-Kaisa, Kettunen Sanna, Suoranta Tuisku, Kaikkonen Minna U, Ylä-Herttuala Seppo, Aherrahrou Rédouane

Abstract excerpt

Despite the advancements and release of new therapeutics in the past few years, cardiovascular diseases (CVDs) have remained the number one cause of death worldwide. Genetic variation of a 9p21.3 genomic locus has been identified as the most significant and robust genetic CVD risk marker on the population level, with the strongest association with coronary artery disease (CAD) and other diseases, including...

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Share to RNA, Circular
Share to Chromosomes, Human, Pair 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Artery Disease

Share to CAD gene

Share to Genetic Loci

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to RNA, Long Noncoding

Source

Identifiers

PMID: 39656484
DOI: 10.1152/ajpheart.00580.2024

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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