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Article

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival.

Molecular and cellular biology - 1 Jul 2009

Wittkopp Nadine, Huntzinger Eric, Weiler Catrin, Saulière Jérôme, Schmidt Steffen, Sonawane Mahendra, Izaurralde Elisa

Abstract excerpt

The nonsense-mediated mRNA decay (NMD) pathway promotes rapid degradation of mRNAs containing premature translation termination codons (PTCs or nonsense codons), preventing accumulation of potentially detrimental truncated proteins. In metazoa, seven genes (upf1, upf2, upf3, smg1, smg5, smg6, and smg7) have been identified as essential for NMD; here we show that the zebrafish genome encodes orthologs of upf1,...

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Identifiers

PMID: 19414594
DOI: 10.1128/MCB.00177-09
PMCID: PMC2698750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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