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SMG1:SMG8:SMG9-complex integrity maintains robustness of nonsense-mediated mRNA decay

2024-04-15

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA turnover pathway, which degrades transcripts containing premature termination codons. SMG1-mediated phosphorylation of the key NMD factor UPF1 is essential for NMD initiation and regulated by SMG9 and the C-terminus of SMG8. However, their specific roles in NMD regulation within intact cells remain partially understood. Here, we deleted the C-termi...

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Literature Corpus work
5bebe5e1-0064-544f-a18c-b6118af236a6
DOI
10.1101/2024.04.15.589496
Open publication

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SMG1:SMG8:SMG9-complex integrity maintains robustness of nonsense-mediated mRNA decayDOI 10.1101/2024.04.15.589496
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