Article
Functions of the nonsense-mediated mRNA decay pathway in Drosophila development.
PLoS genetics - 29 Dec 2006
Metzstein Mark M, Krasnow Mark A
Abstract excerpt
Nonsense-mediated mRNA decay (NMD) is a cellular surveillance mechanism that degrades transcripts containing premature translation termination codons, and it also influences expression of certain wild-type transcripts. Although the biochemical mechanisms of NMD have been studied intensively, its developmental functions and importance are less clear. Here, we describe the isolation and characterization of...
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