Article

UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells

2022-07-04

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a highly conserved regulatory mechanism of post-transcriptional gene expression in eukaryotic cells. NMD plays essential roles in mRNA quality and quantity control, and thus safeguards multiple biological processes including embryonic stem cell differentiation and organogenesis. UPF3A and UPF3B in vertebrate species, originated from a single UPF3 gene in yeast, are key factor...

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Literature Corpus work: 53c49aaf-72f0-531b-8d01-647df435ba58
DOI: 10.1101/2022.07.04.495064

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