Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

15 Jan 2018

Abstract excerpt

BACKGROUND: About 11% of all human genetic diseases are caused by nonsense mutations that generate premature translation termination codons (PTCs) in messenger RNAs (mRNA). PTCs not only lead to the production of truncated proteins, but also often result in decreased mRNA abundance due to nonsense-mediated mRNA decay (NMD). Although pharmacological inhibition of NMD could be an attractive therapeutic approach for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29334995
DOI: 10.1186/s13059-017-1386-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutationsPMID 29334995Read ↗

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.Semantic proximity Read ↗

Truncated RNA-binding protein production by DUX4-induced systemic inhibition of nonsense-mediated RNA decaySemantic proximity Read ↗

[Specific inhibition of nonsense-mediated mRNA decay has the potential to rescue the phenotype of muscular dystrophy].Semantic proximity Read ↗

A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases.Semantic proximity Read ↗

Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts.Semantic proximity Read ↗

Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease.Semantic proximity Read ↗

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival.Semantic proximity Read ↗

UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cellsSemantic proximity Read ↗

Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotidesSemantic proximity Read ↗

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Semantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay Factor Functions in Human Health and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.