Article
Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner.
RNA (New York, N.Y.) - 1 Apr 2011
Avery Paul, Vicente-Crespo Marta, Francis Deepthy, Nashchekina Oxana, Alonso Claudio R, Palacios Isabel M
Abstract excerpt
Nonsense-mediated RNA decay (NMD) is a surveillance mechanism that degrades transcripts containing nonsense mutations, preventing the translation of truncated proteins. NMD also regulates the levels of many endogenous mRNAs. While the mechanism of NMD is gradually understood, its physiological role remains largely unknown. The core NMD genes upf1 and upf2 are essential in several organisms, which may reflect an...
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