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Article

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.

Molecular cell - 19 Nov 2004

Unterholzner Leonie, Izaurralde Elisa

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that eliminates mRNAs containing premature termination codons (PTCs). The proteins UPF1, SMG5, SMG6, and SMG7 are essential NMD factors in metazoa. SMG5 and SMG7 form a complex with UPF1 and interact with each other via their N-terminal domains. Here we show that SMG5 and SMG7 colocalize in cytoplasmic mRNA decay bodies, while SMG6 forms separate...

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Source

Identifiers

PMID: 15546618
DOI: 10.1016/j.molcel.2004.10.013

Genes

SMG7
SMG5
UPF1
SMG6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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