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Article

UPF1 is required for nonsense-mediated mRNA decay (NMD) and RNAi in Arabidopsis.

The Plant journal : for cell and molecular biology - 1 Aug 2006

Arciga-Reyes Luis, Wootton Lucie, Kieffer Martin, Davies Brendan

Abstract excerpt

Aberrant mRNAs containing premature termination codons (PTCs) have the potential to be translated into truncated proteins, which could act to the detriment of the organism by interfering with normal cellular processes. Eukaryotes have mechanisms of mRNA quality control that identify PTC-containing transcripts and target them for destruction, a process known as nonsense-mediated mRNA decay (NMD). Surprising...

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Source

Identifiers

PMID: 16813578
DOI: 10.1111/j.1365-313X.2006.02802.x

Genes

UPF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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UPF1 is required for nonsense-mediated mRNA decay (NMD) and RNAi in Arabidopsis.PMID 16813578Read ↗

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival.Semantic proximity Read ↗

Nonsense-Mediated RNA Decay Factor UPF1 Is Critical for Posttranscriptional and Translational Gene Regulation in Arabidopsis.Semantic proximity Read ↗

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Genome-wide suppression of aberrant mRNA-like noncoding RNAs by NMD in Arabidopsis.Semantic proximity Read ↗

Arabidopsis plants having defects in nonsense-mediated mRNA decay factors UPF1, UPF2, and UPF3 show photoperiod-dependent phenotypes in development and stress responses.Semantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

Nonsense-mediated mRNA decay and development: shoot the messenger to survive?Semantic proximity Read ↗

Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsense-mediated mRNA decay.Semantic proximity Read ↗

The feedback control of UPF3 is crucial for RNA surveillance in plants.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StorySemantic proximity Read ↗

The RNA Polymerase II C-Terminal Domain Phosphatase-Like Protein FIERY2/CPL1 Interacts with eIF4AIII and Is Essential for Nonsense-Mediated mRNA Decay in Arabidopsis.Semantic proximity Read ↗

Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome.Semantic proximity Read ↗

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