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Article

Nonsense-mediated mRNA decay and development: shoot the messenger to survive?

Biochemical Society transactions - 1 Dec 2010

Vicente-Crespo Marta, Palacios Isabel M

Abstract excerpt

NMD (nonsense-mediated mRNA decay) is a surveillance mechanism that degrades transcripts containing nonsense mutations, preventing the translation of potentially harmful truncated proteins. Although the mechanistic details of NMD are gradually being understood, the physiological role of this RNA surveillance pathway still remains largely unknown. The core NMD genes Upf1 (up-frameshift suppressor 1) and Upf2 are...

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Identifiers

PMID: 21118115
DOI: 10.1042/BST0381500
PMCID: PMC3432441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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