Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story

5 Oct 2015

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature translation termination for rapid degradation. From yeasts to humans, activation of NMD requires the function of the three conserved Upf factors: Upf1, Upf2, and Upf3. Here, we summarize the progress in our understanding of the molecular mechanisms of NMD in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA Research and Splicing
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26436458
DOI: 10.1146/annurev-genet-112414-054639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryPMID 26436458Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.Semantic proximity Read ↗

Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants.Semantic proximity Read ↗

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway.Semantic proximity Read ↗

A highly conserved region essential for NMD in the Upf2 N-terminal domain.Semantic proximity Read ↗

Nonsense-mediated mRNA decay and development: shoot the messenger to survive?Semantic proximity Read ↗

Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay Factor Functions in Human Health and DiseaseSemantic proximity Read ↗

Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner.Semantic proximity Read ↗

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival.Semantic proximity Read ↗

Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p.Semantic proximity Read ↗

The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.