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Article

The risk allele load accelerates the age-dependent decline in beta cell function.

Diabetologia - 1 Mar 2009

Haupt A, Staiger H, Schäfer S A, Kirchhoff K, Guthoff M, Machicao F, Gallwitz B, Stefan N, Häring H-U, Fritsche A

Abstract excerpt

AIMS/HYPOTHESIS: Among the novel type 2 diabetes risk loci identified by genome-wide association studies, TCF7L2, HHEX, SLC30A8 and CDKAL1 appear to affect beta cell function. In the present study we examined the effect of these genes' risk alleles on the age-dependent decline in insulin secretion. METHODS: The SNPs rs7903146 (TCF7L2), rs7754840(CDKAL1), rs7923837 (HHEX) and rs13266634 (SLC30A8) were genotyped in...

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Source

Identifiers

PMID: 19172244
DOI: 10.1007/s00125-008-1250-2

Genes

HAL
MAL
CDKAL1
HHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The risk allele load accelerates the age-dependent decline in beta cell function.PMID 19172244Read ↗

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.Semantic proximity Read ↗

Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.Semantic proximity Read ↗

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The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity.Semantic proximity Read ↗

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TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes.Semantic proximity Read ↗

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