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Article

Impact of TCF7L2 rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes.

Diabetes, obesity & metabolism - 1 Apr 2025

Hansen Aleksander L, Andersen Mette K, Engelhard Leonie M, Brøns Charlotte, Hansen Torben, Nielsen Jens S, Vestergaard Peter, Højlund Kurt, Jessen Niels, Olsen Michael H, Thomsen Reimar W, Vaag Allan

Abstract excerpt

AIMS: TCF7L2 rs7903146 is the most impactful single genetic risk variant for type 2 diabetes. However, its role on disease progression, complications and mortality among people with type 2 diabetes at diagnosis remains unclear. MATERIALS AND METHODS: We assessed the per allele impact of the rs7903146 T-allele on clinical characteristics and complication risk in 9231 individuals with type 2 diabetes at diagnosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Alleles
Share to Diabetes Complications
Share to Diabetes Mellitus, Type 2
Share to Diabetic Angiopathies
Share to Polymorphism, Single Nucleotide
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Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 39780311
DOI: 10.1111/dom.16193
PMCID: PMC11885091

Genes

TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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