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Article

Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.

Diabetes - 1 Dec 2010

Heni Martin, Ketterer Caroline, Thamer Claus, Herzberg-Schäfer Silke A, Guthoff Martina, Stefan Norbert, Machicao Fausto, Staiger Harald, Fritsche Andreas, Häring Hans-Ulrich

Abstract excerpt

OBJECTIVE: Several single nucleotide polymorphisms (SNPs) in diabetes risk genes reduce glucose- and/or incretin-induced insulin secretion. Here, we investigated interactions between glycemia and such diabetes risk polymorphisms. RESEARCH DESIGN AND METHODS: Insulin secretion was assessed by insulinogenic index and areas under the curve of C-peptide/glucose in 1,576 subjects using an oral glucose tolerance test...

Topics

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Blood Glucose
C-Peptide
Diabetes Mellitus, Type 2
Glucose Tolerance Test
Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Secreting Cells

Insulin Secretion

Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 20802253
DOI: 10.2337/db10-0674
PMCID: PMC2992789

Genes

WFS1
CDKAL1
HHEX
KCNJ11
KCNQ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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