TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.

doi:10.1371/journal.pone.0021518

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Article

TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.

PloS one - 1 Jan 2011

McCaffery Jeanne M, Jablonski Kathleen A, Franks Paul W, Dagogo-Jack Sam, Wing Rena R, Knowler William C, Delahanty Linda, Dabelea Dana, Hamman Richard, Shuldiner Alan R, Florez Jose C

Abstract excerpt

AIMS: TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses. METHODS: We examined the potential role of the TCF7L2 rs7903146 variant in predicting resistance to weight loss or a lack of improvement of proinsulin...

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PMID: 21814547
DOI: 10.1371/journal.pone.0021518
PMCID: PMC3144193

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