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Article

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

Diabetologia - 1 Apr 2008

Kirchhoff K, Machicao F, Haupt A, Schäfer S A, Tschritter O, Staiger H, Stefan N, Häring H-U, Fritsche A

Abstract excerpt

AIMS/HYPOTHESIS: Variation within six novel genetic loci has been reported to confer risk of type 2 diabetes and may be associated with beta cell dysfunction. We investigated whether these polymorphisms are also associated with impaired proinsulin to insulin conversion. METHODS: We genotyped 1,065 German participants for single nucleotide polymorphisms rs7903146 in TCF7L2, rs7754840 in CDKAL1, rs7923837 and...

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Share to C-Peptide
Share to Cyclin-Dependent Kinase 5
Share to Insulin Secretion
Share to Proinsulin
Share to TCF Transcription Factors
Share to Transcription Factor 7-Like 2 Protein
Share to tRNA Methyltransferases
Share to Zinc Transporter 8

Source

Identifiers

PMID: 18264689
DOI: 10.1007/s00125-008-0926-y

Genes

CDKAL1
HHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.PMID 18264689Read ↗

The risk allele load accelerates the age-dependent decline in beta cell function.Semantic proximity Read ↗

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Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with impaired proinsulin conversion--A meta-analysis.Semantic proximity Read ↗

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