Article
Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.
Diabetes - 1 Jan 2010
't Hart Leen M, Simonis-Bik Annemarie M, Nijpels Giel, van Haeften Timon W, Schäfer Silke A, Houwing-Duistermaat Jeanine J, Boomsma Dorret I, Groenewoud Marlous J, Reiling Erwin, van Hove Els C, Diamant Michaela, Kramer Mark H H, Heine Robert J, Maassen J Antonie, Kirchhoff Kerstin, Machicao Fausto, Häring Hans-Ulrich, Slagboom P Eline, Willemsen Gonneke, Eekhoff Elisabeth M, de Geus Eco J, Dekker Jacqueline M, Fritsche Andreas
Abstract excerpt
OBJECTIVE: At least 20 type 2 diabetes loci have now been identified, and several of these are associated with altered beta-cell function. In this study, we have investigated the combined effects of eight known beta-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps. RESEARCH DESIGN AND METHODS: A total of 447 subjects originating from four independent studies...
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