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Article

Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.

Diabetologia - 1 Nov 2008

Pascoe L, Frayling T M, Weedon M N, Mari A, Tura A, Ferrannini E, Walker M

Abstract excerpt

AIMS/HYPOTHESIS: Novel type 2 diabetes-susceptibility loci have been identified with evidence that individually they mediate the increased diabetes risk through altered pancreatic beta cell function. The aim of this study was to test the cumulative effects of diabetes-risk alleles on measures of beta cell function in non-diabetic individuals. METHODS: A total of 1,211 non-diabetic individuals underwent metabolic...

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Source

Identifiers

PMID: 18719881
DOI: 10.1007/s00125-008-1124-7

Genes

CDKAL1
HHEX
IDE
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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