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Article

The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity.

The Journal of clinical endocrinology and metabolism - 1 May 2009

Haupt Axel, Guthoff Martina, Schäfer Silke A, Kirchhoff Kerstin, Machicao Fausto, Gallwitz Baptist, Staiger Harald, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich

Abstract excerpt

CONTEXT/OBJECTIVE: Recently novel type 2 diabetes risk loci were identified and reported to associate with beta-cell dysfunction. We assessed whether the risk alleles in TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A/2B, JAZF1, and WFS1 reduce insulin secretion in an additive manner and whether their impact is influenced by insulin sensitivity. DESIGN/METHODS: We genotyped 1397 nondiabetic subjects for the...

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Insulin Resistance

Insulin-Secreting Cells

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Identifiers

PMID: 19258404
DOI: 10.1210/jc.2008-1876

Genes

CDKAL1
HHEX
JAZF1
WFS1

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The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity.PMID 19258404Read ↗

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Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.Semantic proximity Read ↗

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