TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

doi:10.2337/db09-1169

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Article

TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

Diabetes - 1 Feb 2010

Villareal Dennis T, Robertson Heather, Bell Graeme I, Patterson Bruce W, Tran Hung, Wice Burton, Polonsky Kenneth S

Abstract excerpt

OBJECTIVE: Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS: Eight subjects with risk-conferring TCF7L2 genotypes (TT or TC at rs7903146) and 10 matched subjects with wild-type genotype (CC) underwent 5-h oral...

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PMID: 19934000
DOI: 10.2337/db09-1169
PMCID: PMC2809956

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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.PMID 19934000Read ↗

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