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Article

Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.

Diabetes/metabolism research and reviews - 1 Jul 2011

Silbernagel Guenther, Renner Wilfried, Grammer Tanja B, Hügl Sigrun R, Bertram Julia, Kleber Marcus E, Hoffmann Michael M, Winkelmann Bernhard R, März Winfried, Boehm Bernhard O

Abstract excerpt

BACKGROUND: Variants in TCF7L2 have been associated with the age at onset of type 2 diabetes in Mexican Americans. However, there is a lack of data on this relationship in Caucasians. Furthermore, risk alleles in TCF7L2 have been suggested to account for decreased conversion of proinsulin to insulin and decreased expression of GLP-1. We investigated the effect of the allelic variants rs1225537 and rs7903146 in...

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PMID: 21384500
DOI: 10.1002/dmrr.1194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.PMID 21384500Read ↗

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