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Article

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.

Diabetes - 1 Dec 2007

Pascoe Laura, Tura Andrea, Patel Sheila K, Ibrahim Ibrahim M, Ferrannini Ele, Zeggini Eleftheria, Weedon Michael N, Mari Andrea, Hattersley Andrew T, McCarthy Mark I, Frayling Timothy M, Walker Mark

Abstract excerpt

OBJECTIVE: Type 2 diabetes is characterized by impaired pancreatic beta-cell function and decreased insulin sensitivity. Genome-wide association studies have identified common, novel type 2 diabetes susceptibility loci within the FTO, CDKAL1, CDKN2A/CDKN2B, IGF2BP2, HHEX/IDE, and SLC30A8 gene regions. Our objective was to explore the relationships between the diabetes-associated alleles and measures of beta-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17804762
DOI: 10.2337/db07-0634

Genes

CDKAL1
HHEX
IDE
FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.PMID 17804762Read ↗

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