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Article

Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Feb 2009

Corsentino Elizabeth A, Sawyer Kathryn, Sachs-Ericsson Natalie, Blazer Dan G

Abstract excerpt

OBJECTIVES: The apolipoproteinE epsilon4 (APOE epsilon4) allele and a history of depression are each separate risk factors for cognitive decline (CD). However, little research has investigated whether a history of depression influences the relationship between APOE epsilon4 and CD. The present study examined whether depressive symptoms had greater influence on subsequent CD among participants with APOE epsilon4...

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Source

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Identifiers

PMID: 19155747
DOI: 10.1097/JGP.0b013e31818f3a6b
PMCID: PMC2744964

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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