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Article

The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons.

JAMA - 7 Jul 1999

Haan M N, Shemanski L, Jagust W J, Manolio T A, Kuller L

Abstract excerpt

CONTEXT: Cognitive decline in elderly persons is often an early predictor of dementia. Subclinical cardiovascular disease (CVD) and diabetes mellitus may contribute to substantial decline in cognitive function in the elderly. These risks may be modified by gene-environment interactions between apolipoprotein E (APOE) genotype and CVD risk factors or subclinical CVD. OBJECTIVES: To examine the association between...

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Source

Identifiers

PMID: 10404910
DOI: 10.1001/jama.282.1.40

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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