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Article

Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study.

Archives of general psychiatry - 1 Aug 2008

Irie Fumiko, Masaki Kamal H, Petrovitch Helen, Abbott Robert D, Ross G Webster, Taaffe Dennis R, Launer Lenore J, White Lon R

Abstract excerpt

CONTEXT: The apolipoprotein E epsilon4 (APOE epsilon4) allele is a genetic risk factor for Alzheimer disease. Recently, depression has also become recognized as a risk factor for dementia. However, the possible effect of the APOE genotype on the association between depression and dementia is unexamined. OBJECTIVE: To examine the independent and combined effects of depression and APOE epsilon4 on the risk of...

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Identifiers

PMID: 18678795
DOI: 10.1001/archpsyc.65.8.906
PMCID: PMC4791584

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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