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Article

Gene-behavior interaction of depressive symptoms and the apolipoprotein E {varepsilon}4 allele on cognitive decline.

Psychosomatic medicine - 1 Feb 2014

Rajan Kumar B, Wilson Robert S, Skarupski Kimberly A, Mendes de Leon Carlos F, Evans Denis A

Abstract excerpt

OBJECTIVE: Depressive symptoms and the apolipoprotein E (APOE) ε4 allele are independent risk factors for cognitive decline. However, it is not clear whether the presence of both depressive symptoms and the APOE ε4 allele increases cognitive decline. METHODS: A prospective study of a population-based sample of 4150 (70% African American and 63% women) participants 65 years and older who were interviewed at 3-year...

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Identifiers

PMID: 24434953
DOI: 10.1097/PSY.0000000000000029
PMCID: PMC4142223

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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