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Article

APOE genotype and cognitive decline in a middle-aged cohort.

Neurology - 25 Jan 2005

Blair C K, Folsom A R, Knopman D S, Bray M S, Mosley T H, Boerwinkle E

Abstract excerpt

BACKGROUND: Most longitudinal studies of nondemented persons have reported greater cognitive decline among APOE epsilon4 carriers vs noncarriers. However, most studies involved elderly samples (aged 65+) and were not large enough to examine the three APOE alleles separately. METHODS: Change in cognitive function was examined over a 6-year period using three neuropsychological tests among four APOE genotype groups...

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Source

Identifiers

PMID: 15668424
DOI: 10.1212/01.WNL.0000149643.91367.8A

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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